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Lethal trap for Edith’s checkerspot butterfly

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Letter | 09 May 2018

/>Vector-based navigation using grid-like representations in artificial agents

Grid-like representations emerge spontaneously within a neural network trained to self-localize, enabling the agent to take shortcuts to destinations using vector-based navigation.

  • Andrea Banino
  • , Caswell Barry
  • , Benigno Uria
  • , Charles Blundell
  • , Timothy Lillicrap
  • , Piotr Mirowski
  • , Alexander Pritzel
  • , Martin J. Chadwick
  • , Thomas Degris
  • , Joseph Modayil
  • , Greg Wayne
  • , Hubert Soyer
  • , Fabio Viola
  • , Brian Zhang
  • , Ross Goroshin
  • , Neil Rabinowitz
  • , Razvan Pascanu
  • , Charlie Beattie
  • , Stig Petersen
  • , Amir Sadik
  • , Stephen Gaffney
  • , Helen King
  • , Koray Kavukcuoglu
  • , Demis Hassabis
  • , Raia Hadsell
  • & Dharshan Kumaran

Letter | 09 May 2018

Challenging local realism with human choices

The BIG Bell Test, which used an online video game with 100,000 participants worldwide to provide random bits to 13 quantum physics experiments, contradicts the Einstein–Podolsky–Rosen worldview of local realism.

Article | 09 May 2018

Reconstitution reveals motor activation for intraflagellar transport

Reconstitution of a functional intraflagellar transport complex in Caenorhabditis elegans provides insight into the recruitment and activation of the kinesin-2 motor protein.

  • Mohamed A. A. Mohamed
  • , Willi L. Stepp
  • & Zeynep Ökten

Letter | 09 May 2018

Self-reporting and self-regulating liquid crystals

Liquid crystals are used to self-report and self-regulate either continuous or transient release of droplets or microparticles trapped within them in response to thermal, chemical, mechanical or biological stimuli.

  • Young-Ki Kim
  • , Xiaoguang Wang
  • , Pranati Mondkar
  • , Emre Bukusoglu
  • & Nicholas L. Abbott

Current Issue | 10 May 2018

Letter | 09 May 2018

Ancient hepatitis B viruses from the Bronze Age to the Medieval period

Phylogenies reconstructed using 12 hepatitis B virus genomes, which were recovered from ancient human genome data, reveal a complex history of hepatitis B evolution that is not evident when using only modern samples.

  • Barbara Mühlemann
  • , Terry C. Jones
  • , Peter de Barros Damgaard
  • , Morten E. Allentoft
  • , Irina Shevnina
  • , Andrey Logvin
  • , Emma Usmanova
  • , Irina P. Panyushkina
  • , Bazartseren Boldgiv
  • , Tsevel Bazartseren
  • , Kadicha Tashbaeva
  • , Victor Merz
  • , Nina Lau
  • , Václav Smrčka
  • , Dmitry Voyakin
  • , Egor Kitov
  • , Andrey Epimakhov
  • , Dalia Pokutta
  • , Magdolna Vicze
  • , T. Douglas Price
  • , Vyacheslav Moiseyev
  • , Anders J. Hansen
  • , Ludovic Orlando
  • , Simon Rasmussen
  • , Martin Sikora
  • , Lasse Vinner
  • , Albert D. M. E. Osterhaus
  • , Derek J. Smith
  • , Dieter Glebe
  • , Ron A. M. Fouchier
  • , Christian Drosten
  • , Karl-Göran Sjögren
  • , Kristian Kristiansen
  • & Eske Willerslev

Letter | 09 May 2018 | open

Genome sequence of the progenitor of wheat A subgenome Triticum urartu

The genome sequence of Triticum urartu, the progenitor of the A subgenome of hexaploid wheat, provides insight into genome duplication during grass evolution.

  • Hong-Qing Ling
  • , Bin Ma
  • , Xiaoli Shi
  • , Hui Liu
  • , Lingli Dong
  • , Hua Sun
  • , Yinghao Cao
  • , Qiang Gao
  • , Shusong Zheng
  • , Ye Li
  • , Ying Yu
  • , Huilong Du
  • , Ming Qi
  • , Yan Li
  • , Hongwei Lu
  • , Hua Yu
  • , Yan Cui
  • , Ning Wang
  • , Chunlin Chen
  • , Huilan Wu
  • , Yan Zhao
  • , Juncheng Zhang
  • , Yiwen Li
  • , Wenjuan Zhou
  • , Bairu Zhang
  • , Weijuan Hu
  • , Michiel J. T. van Eijk
  • , Jifeng Tang
  • , Hanneke M. A. Witsenboer
  • , Shancen Zhao
  • , Zhensheng Li
  • , Aimin Zhang
  • , Daowen Wang
  • & Chengzhi Liang

Article | 09 May 2018

Diverse reprogramming codes for neuronal identity

A screen in which combinatorial pairs of transcription factors are exogenously expressed in fibroblasts identifies different combinations that reprogram these cells into induced neuronal cells with diverse functional properties.

  • Rachel Tsunemoto
  • , Sohyon Lee
  • , Attila Szűcs
  • , Pavel Chubukov
  • , Irina Sokolova
  • , Joel W. Blanchard
  • , Kevin T. Eade
  • , Jacob Bruggemann
  • , Chunlei Wu
  • , Ali Torkamani
  • , Pietro Paolo Sanna
  • & Kristin K. Baldwin

Letter | 09 May 2018

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation

A new model of cardiac trabeculation in mice is presented in which NOTCH1 and NRG1 have opposing roles in extracellular matrix degradation and synthesis that are essential for defining trabecular architecture.

  • Gonzalo del Monte-Nieto
  • , Mirana Ramialison
  • , Arne A. S. Adam
  • , Bingruo Wu
  • , Alla Aharonov
  • , Gabriele D’Uva
  • , Lauren M. Bourke
  • , Mara E. Pitulescu
  • , Hanying Chen
  • , José Luis de la Pompa
  • , Weinian Shou
  • , Ralf H. Adams
  • , Sarah K. Harten
  • , Eldad Tzahor
  • , Bin Zhou
  • & Richard P. Harvey

Letter | 09 May 2018

Rapid energy-efficient manufacturing of polymers and composites via frontal polymerization

Frontal polymerization of dicyclopentadiene is used to generate thermoset polymers and composite materials with much lower energy requirements and cure times than are needed in conventional oven or autoclave curing approaches.

  • Ian D. Robertson
  • , Mostafa Yourdkhani
  • , Polette J. Centellas
  • , Jia En Aw
  • , Douglas G. Ivanoff
  • , Elyas Goli
  • , Evan M. Lloyd
  • , Leon M. Dean
  • , Nancy R. Sottos
  • , Philippe H. Geubelle
  • , Jeffrey S. Moore
  • & Scott R. White

Letter | 09 May 2018

Lethal trap created by adaptive evolutionary response to an exotic resource

Local extinction of the butterfly Euphydryas editha occurred after the population was caught in an eco-evolutionary trap set when the insects evolved unanimous preference for an exotic host, Plantago lanceolata, and sprung when that host became embedded in grasses after humans removed cattle.

  • Michael C. Singer
  • & Camille Parmesan

Letter | 09 May 2018

Self-reporting and self-regulating liquid crystals

Liquid crystals are used to self-report and self-regulate either continuous or transient release of droplets or microparticles trapped within them in response to thermal, chemical, mechanical or biological stimuli.

  • Young-Ki Kim
  • , Xiaoguang Wang
  • , Pranati Mondkar
  • , Emre Bukusoglu
  • & Nicholas L. Abbott

Letter | 09 May 2018

Precision measurement of the weak charge of the proton

Measurement of the asymmetry in the parity-violating scattering of polarized electrons on protons gives the weak charge of the proton as 0.0719 ± 0.0045, in agreement with the standard model.

Letter | 09 May 2018

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

Distinct strains of misfolded α-synuclein proteins, which aggregate in neurons in Lewy body diseases or in oligodendrocytes in multiple system atrophy, are formed as a consequence of differences between intracellular environments.

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